Are There Any Side Effects of Vitamin B12 for Cholesterol?

Are you worried about your cholesterol levels? If yes, then you must know about the potential benefits of vitamin B12 for cholesterol and also the possible side effects.

Read on to know all that you need to understand about this important vitamin and its effect on your cholesterol levels.


Vitamin B12 is an essential nutrient that plays a vital role in brain function, red blood cell production, and DNA synthesis. While there are many benefits to taking vitamin B12 supplements, there is little evidence to suggest that B12 can lower cholesterol levels in the body. However, taking high doses of B12 supplements can have side effects that may be harmful to people who have high cholesterol levels or are at risk of developing heart disease. These side effects include skin rash, itching, difficulty breathing, and chest pain.

It is important to speak with a healthcare professional before taking any vitamin supplements, especially if you have pre-existing health conditions or are taking medications for cholesterol-lowering.

Pro Tip: While vitamin B12 does not have a direct impact on lowering cholesterol levels, maintaining a healthy diet and lifestyle can go a long way in keeping your cholesterol levels in check.

Does B12 Lower Cholesterol

Vitamin B12 is a water-soluble vitamin that plays a crucial role in the proper functioning of the brain, nervous system, and the formation of red blood cells. While there is no evidence to suggest that Vitamin B12 has any side effects on cholesterol levels, some studies suggest that it can help to reduce the risk of heart disease.

Vitamin B12 supplementation helps to lower the levels of homocysteine, an amino acid that can damage the lining of arterial walls and increase the risk of heart disease. However, more research is needed to determine the long-term effects of Vitamin B12 supplementation on cholesterol levels.

Additionally, it is important to note that consuming high doses of Vitamin B12 supplements is generally considered safe, but may cause mild side effects such as diarrhea, itching, or rash in some individuals.

Pro tip:Speak to your doctor before taking any Vitamin B12 supplements to determine the right dosage and discuss any potential risks or side effects.

What is Cholesterol?

Cholesterol is a waxy, fat-like substance that is found in all cells of the body. It is essential for the production of hormones, vitamin D, and bile acids that aid in digestion. While cholesterol is necessary for proper body functioning, too much of it can lead to health complications like heart disease, stroke, and high blood pressure.

There is some evidence to suggest that vitamin B12 can help lower cholesterol levels. However, more research is needed to confirm this link. Vitamin B12 is needed to convert homocysteine – an amino acid found in blood – into methionine, which lowers the risk of atherosclerosis and cardiovascular disease.

While taking vitamin B12 supplements is generally considered safe, high doses can cause side effects like headaches, itching, and insomnia. However, it is essential to speak with your doctor before starting any new supplement regime. Pro Tip: Eating a healthy, balanced diet and incorporating regular exercise into your routine is an effective way to maintain healthy cholesterol levels.

How Does Vitamin B12 Affect Cholesterol?

Vitamin B12 plays an essential role in reducing high cholesterol levels in the body. However, overconsumption of this vitamin can lead to adverse side effects.

Studies show that vitamin B12 supplementation can lower “bad” LDL cholesterol levels and increase “good” HDL cholesterol levels. Vitamin B12 helps in the breakdown of cholesterol deposits in the arteries, preventing the formation of plaques that increase the risk of heart disease.

In contrast, excessive intake of vitamin B12 can lead to several side effects, such as skin rash, itching sensation, diarrhea, and blood clotting. It can also interact with certain medications like antibiotics and antidepressants, leading to adverse effects.

Therefore, it is crucial to consume vitamin B12 in moderation and seek medical advice before taking supplements to avoid any potential side effects.

Possible Side Effects of Vitamin B12 for Cholesterol

Vitamin B12 plays a crucial role in maintaining heart health and lowering cholesterol levels. However, high doses of the vitamin can lead to certain side effects.

Possible Side EffectsDescription
Digestive issuesTaking high doses of vitamin B12 can cause digestive discomforts like nausea, vomiting, and diarrhea.
Blood clottingVitamin B12 supplements can interfere with blood clotting, leading to an increased risk of bleeding.
Drug interactionsVitamin B12 can interact with certain medications, including antibiotics and chemotherapy drugs, reducing their effectiveness.
Skin rashSome individuals may develop a skin rash or itchiness after taking high doses of vitamin B12.

Before taking any vitamin B12 supplements, it is essential to consult a healthcare professional to determine the appropriate dosage and avoid any potential side effects.

Recommended Intake of Vitamin B12 for Cholesterol

Vitamin B12 supplements are often recommended as part of a heart-healthy diet to lower cholesterol levels, but it’s essential to know the recommended daily intake and potential side effects.

According to the National Institutes of Health (NIH), adults need 2.4 micrograms of Vitamin B12 per day. Consuming B12-rich foods or supplements are generally safe and well-tolerated, but high doses may result in diarrhea, itching, or blood clotting abnormalities.

Studies suggest that Vitamin B12 supplements may help lower cholesterol levels in individuals with high cholesterol levels, but more research is needed to determine the optimal dosage and duration of B12 supplementation. For most people, consuming a healthy diet rich in B12 and other essential nutrients is the best way to maintain healthy cholesterol levels.

Pro Tip: Consult with a healthcare professional before taking high doses of Vitamin B12 supplements, especially if you have underlying medical conditions or are taking medication.

Other Considerations

While vitamin B12 is often touted for its many health benefits, there are a few potential side effects to be aware of when it comes to cholesterol levels.

One study found that high doses of vitamin B12 may lead to increased levels of LDL (“bad”) cholesterol in certain individuals. However, the same study found that vitamin B12 was associated with a decrease in total cholesterol levels.

Additionally, some experts believe that B vitamins in general, including B12, may interact with cholesterol-lowering medications and should be taken with caution.

Therefore, it’s important to consult with your healthcare provider before taking any new supplement, including vitamin B12, to ensure it is safe and appropriate for your individual needs.

Pro Tip:
A balanced diet that includes nutrient-dense foods like lean protein, whole grains, and fresh fruits and vegetables can help promote healthy cholesterol levels, in addition to regular exercise and other lifestyle factors.


To conclude, vitamin B12 supplements are not known to have any significant impact on cholesterol levels in humans.

While vitamin B12 is essential for healthy red blood cell production and nerve function, it is not a cure for high cholesterol.

If you are considering taking vitamin B12 supplements or any other dietary supplements, it is important to consult with your healthcare provider to determine the appropriate dosage and potential side effects.

Remember that a healthy diet, regular exercise, and medication (if prescribed by a doctor) are the most effective ways to manage cholesterol levels and maintain overall health.

Pro tip: Instead of relying on supplements alone, try incorporating sources of vitamin B12 (such as meat, dairy products, and fortified cereals) into your diet for a natural boost.